منابع مشابه
Translating antibody insights.
VIRUSES THAT DEFY HOST IMMUNE RESPONSES AND PERSIST OR RECUR TAKE A HUGE TOLL ON GLOBAL human health. Many of these, including HIV-1, infl uenza viruses, and several fl aviviruses (such as dengue, hepatitis C, and West Nile virus) rapidly proliferate, frequently mutate, and evolve highly variable surface structures. The effectiveness of such immune escape mechanisms has thwarted multiple attemp...
متن کاملTranslating molecular insights in autoimmunity into effective therapy.
Autoimmunity and the pathogenesis of autoimmune diseases were a major focus of the Walter and Eliza Hall Institute, where I started my research career. After my initial studies on immune cell culture and immune regulation, I returned to an analysis of the pathogenesis of human autoimmunity in London. Linking upregulated antigen presentation to autoimmunity led to an investigation of the role of...
متن کاملAGS, SLE, and RNASEH2 mutations: translating insights into therapeutic advances.
Systemic lupus erythematosus (SLE) is a severe autoimmune disease characterized by the presence of nucleic acid- and protein-targeting autoantibodies and an aberrant type I IFN expression signature. Aicardi-Goutières syndrome (AGS) is an autosomal-recessive encephalopathy in children that is characterized by mutations in numerous nucleic acid repair enzymes and elevated IFN levels. Phenotypical...
متن کاملLaunch of BBA Clinical: Translating molecular insights to clinical research
Biochimica et Biophysica Acta (BBA) began publication in 1947. It was the first international journal dedicated to the publication of new findings from the emerging and synergistic fields of biochemistry and biophysics. Since that time, the titles within the BBA series have expanded to meet the needs of scientists focused on understanding the physics, molecular mechanisms, and biochemical under...
متن کاملTranslating insights of AR signaling from mouse models
Androgen receptor (AR) signaling plays a critical role in the physiology of the prostate and thus the biology of prostate cancer. Agents targeting the AR pathway have been the mainstay of treatment for patients with locally advanced and metastatic prostate cancer. In this review we will cover the role of androgen signaling in prostate cancer mouse models with an emphasis on how tumorigenic mole...
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ژورنال
عنوان ژورنال: Science
سال: 2013
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1245018